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These pathological changes have been associated with progressive reductions in gray and white matter volumes in critical brain regions responsible for cognitive functions 13,25

Over the years, various mechanisms have been found to be responsible for its antioxidant activities in both in vitro and in vivo models

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After overeating, Wnt/-catenin signal transduction in adipose tissue is inhibited, manifesting as increased expression of inhibitors of the canonical Wnt signalling pathway, such as SFRP2, FRZB/SFRP3, and DKK3, and increased phosphorylation and total GSK-3 levels

10.1136/gut.50.2.241 131

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