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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.McMichael M.A., Freeman L.M., Selhub J., Rozanski E.A., Brown D.J., Nadeau M.R., Rush J.E

There is some limited preclinical data that it could impact tissues involved in reproduction, but direct, reliable evidence showing a connection to improved human fertility is missing at this time

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Published preclinical toxicology studies have approached this challenge through empirical observation: exposing animal models to BPC-157 at concentrations exceeding those used in efficacy studies and documenting effects on general health, organ function, clinical pathology parameters, and histopathology

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With cisplatin for initial treatment of locally advanced or metastatic nonsquamous NSCLC: This drug should be administered before cisplatin on Day 1 of each 21-day cycle for up to 6 cycles in the absence of disease progression or unacceptable toxicity