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Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem

Dosing tiers: Morning dosing maximizes synergy with daytime physical activity

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Independent Verification: Every batch is tested to confirm the absence of heavy metals and cross-contaminants

AOD9604 RCT summary and clinical efficacy Annals of Clinical and Laboratory Science (PubMed) Effect of intraarticular AOD9604 with hyaluronic acid in rabbit osteoarthritis model DrugBank AOD9604 drug summary

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