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Cisplatin combined with metformin inhibits migration and invasion of human nasopharyngeal carcinoma cells by regulating E-cadherin and MMP-9

Pisle, S

Coskun and colleagues (Cell Metabolism, 2022) provided the foundational characterisation, demonstrating that balanced engagement of all three receptors produces metabolic effects not achievable through dual or single-receptor pharmacology alone

Clinical data is lacking

In addition to this investigation into stroke-induced cognitive dysfunction, researchers at the University of California, Irvine, tested the efficacy of NSI-189 as a treatment for the cognitive decline associated with radiation therapy

Faster Results Most patients feel effects within 3060 minutes, versus hours or days with oral supplements