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Gene silencing by small interfering (siRNA) and short hairpin RNAs (shRNA) Transient and stable gene silencing by siRNA and shRNA, respectively, was performed as previously described 11

Notably, downregulation of the polycomb repressive complex (PRC2) histone methyltransferase gene EZH1 contributes to reduced gene silencing

This limitation hinders research to clarify the dynamic role of metabolites and metabolic rewiring across heterogeneous tissues in health and disease

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