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Early work in mouse skeletal muscle also helps explain why users notice changes first in energy and then in body composition

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Nature 610 , 796803 (2022)

When liver and other cells require more cholesterol than they can produce, they synthesise LDL receptors, which are inserted into the plasma membrane to associate with clathrin-coated pits and recognize Apo B-100 and Apo E to mediate the uptake of LDL derived from triacylglycerol-depleted VLDL

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