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In metabolic syndrome, multiple factors due to oxidative stress cooperate to promote the progression of hypertension, including inflammatory adipokines, activation of the sympathetic nervous system, abnormal gut microbiota, and retention of water and sodium [131]

doi:10.7326/0003-4819-141-6-200409210-00006 Lee, Ji-Eun

However, a deeper understanding of cereblon-based PROTACs is needed in various aspects, starting from their design and synthesis to their clinical evaluation

Oberst, A

Cancer 20 , 126 (2021)

MYC expression being a common property of all proliferating cells, the intrinsically disordered location of its main functional domains in addition to the protein localization inside the nucleus and its short half-life, collectively these properties raise the challenge to find innovative ways to target MYC without causing unacceptable toxicities