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Fisker, S

To this end, we treated cystine-starved cells with GSHee, (a membrane-permeable analog of GSH) and found that GSHee rescued mTORC1 signaling and ISR (Fig

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This process is mediated by the system xc antiporter, composed of solute carrier family 7 member 11 (SLC7A11, also known as xCT) and its chaperone solute carrier family 3 member 2 (SLC3A2, also known as CD98)

As expected, there was a surge in Gid4 expression within the first hour after glucose was restored to carbon-starved yeast, followed by progressive decrease over time

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