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PLoS One 11, e0162733

If symptoms include worsening pain, weakness, numbness, fever, unexplained weight loss, chest pain, severe fatigue, or new neurologic symptoms, patients should seek medical evaluation instead of relying on wellness therapies alone

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Additional precautions include sedation, dizziness, tremor, weight gain, and potential metabolic effects (e.g., changes in appetite or polycystic ovary syndrome features)

Exogenous antioxidantsDouble-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses

Another study revealed Mrp3 as an alternative exporter of bile acids and glucuronides from cholestatic hepatocytes, but the pump was not involved in the enterohepatic circulation of bile acids in Mrp3 knockout mice models[82]