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Nuclear factor-kappa B (NF-B) is a transcription factor that binds DNA and induces the transcription of the COX-2 gene, other pro-inflammatory genes, as well as genes involved in cell proliferation, adhesion, survival, and differentiation

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209,210 For targeted NADs, including ASO and siRNA, when the relevant genetic information of the disease is determined, lead compounds can be designed for the gene sequence to avoid off-target effects during development

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These intramuscular injections, usually containing cyanocobalamin or methylcobalamin, are administered weekly or monthly as prescribed by a healthcare provider