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Taken together, the uncontrolled production and decreased utilization of substrates lead to the disease states hallmark hyperglycemia and hyperinsulinemia (324)

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Sinha, P

doi: 10.1242/jcs.1125880 114 ShimoiK.OkadaH.FurugoriM.GodaT.TakaseS.SuzukiM.et al

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The key oxidative enzyme of the PPP is glucose 6-phosphate dehydrogenase (G6PDH), which catalyzes the first reaction of the pathway to generate NADPH
