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Annals of Oncology

Co-culturing ferroptotic cancer cells with dendritic cells (DCs) reveals that ferroptotic cells decrease maturation of DCs and dampen antigen cross-presentation, and hence inhibit adaptive immune response and promote tumor growth [232]

ButlerCCGillespieDWhitePBatesJLoweRThomas-JonesEet al

N.StrigoI

Testing should include: Erythrocyte sedimentation rate, C-reactive protein, and antinuclear antibodies: though these are nonspecific markers of inflammation, they may support an immune-mediated etiology if positive Extractable nuclear antigen panel: Sjgren syndrome A and B autoantibodies are the most important components in this setting 5,11 The Schirmer test or salivary gland biopsy should be considered for seronegative patients with sicca or a suspected immune-mediated etiology, as the sensitivity of antibody testing ranges from only 10% to 55%

Adam Friedman, MD, is a professor and chair of dermatology at The George Washington University School of Medicine & Health Sciences in Washington, D.C