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Facteurs influenant la plage normale: lge, lalimentation et ltat de sant gnral peuvent influencer les niveaux de vitamine B12. Les laboratoires peuvent utiliser des plages de rfrence lgrement diffrentes en fonction de leurs mthodes de test

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Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis