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Three-dimensional structures are known for a number of the relevant enzymes, including mycobacterial EgtB (101) for example, PDB 4XBE, EgtC (102) for example, PDB 4ZFJ, EgtD (103105) for example, PDB 4PIM, and Neurospora crassa early G1 transcript 2 (egt2) which is like egtE (106) for example, PDB 5UTS

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It also underscores why replenishing glutathioneeither directly or through precursorsis a primary therapeutic target for neuroinflammation

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This literature search served as an aid in developing optimized study protocols and selecting compounds for the in vitro alkaline comet assay with liver models, including appropriate NA reference compounds