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The NO/cGMP/PKG pathway in platelets: the therapeutic potential of PDE5 inhibitors in platelet disorders
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In addition, the effect of low-dose naltrexone (4.5 mg/day) on daily self-reported pain and overall life satisfaction, positive mood, sleep quality and fatigue was investigated in a small cohort of patients [89]

Behavioral assessment included a comprehensive battery: three-chamber social interaction, social novelty, marble burying, self-grooming, open-field, elevated plus maze, tail suspension, and forced-swim test
