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57, 126.10.1124/pr.57.1.1 36 KrullK.BrouwersM.JainN.ZhangL.BomgaarsL.DreyerZ.et al (2008)

Within 3060 seconds of irradiation, irradiated cells or irradiated medium have been separated from non-irradiated cells, and it has been discovered that the likelihood of bystander effects manifesting was greatly decreased (108, 138)

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For example, collagen and fibronectin in the ECM can synergistically activate PI3K/Akt signaling, causing increased cancer cell resistance to cisplatin
Topical forms remain Category 1 (eligible for compounding)

Ann N Y Acad Sci 1348:97106 Orallo F (2006) Comparative studies of the antioxidant effects of cis- and trans-resveratrol
