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if contact occurs, rinse thoroughly with water Wash hands after each application A short adjustment period is normal mild dryness, flaking, or a sensation of warmth during the first 26 weeks is expected with tretinoin use and typically resolves as the skin adapts Using a gentle, fragrance-free moisturizer 1015 minutes before applying Stella+ (the "sandwich" technique) can help manage initial retinoid irritation for sensitive skin This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient

Zhao M, Bai Y, Xie W et al (2015) Interleukin-1 level is increased in vitreous of patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV)

Its use requires vigilance for adverse effects, most notably potential hepatotoxicity, which necessitates regular monitoring of liver function

10.1007/s13311-020-00968-6 139 SantocchiE.GuiducciL

Feb 19 2021;22(4)doi:10.3390/ijms22042048 Qi X, Yun C, Sun L, et al