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[49] ERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli such as epidermal growth factor, [50] whereas the JNK and p38 MAPK are activated by the MAPK kinase, activated themselves by the TGF--activated kinase-1 (TAK1) upon stress stimuli

One published study in the International Journal of Dermatology reported meaningful improvements in hair shaft diameter after 6 months of use