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doi:10.1067/mhn.2000.105415 Gamiz MJ, Lopez-Escamez JA

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Isocitrate dehydrogenases (IDH) IDH also facilitates the generation of NADPH from NADP + by catalyzing the oxidative decarboxylation of isocitrate to -ketoglutarate (-KG) for TCA cycle

Other drugs like pramipexole, memantine, carvedilol, and melatonin have been reported to activate CREB/RCAN1 and Nrf2 pathways

Gorter TM, van Woerden G, Rienstra M, Dickinson MG, Hummel YM, Voors AA, et al

Along these lines, several studies have shown that administration of the GSH precursor, N-acetylcysteine, just prior to or immediately after TBI, significantly preserved brain tissue and mitochondrial GSH levels, reduced oxidative damage, and preserved neuronal survival (Xiong et al., 1999