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High doses of B12 may worsen the disease and cause irreversible damage to the optic nerve
Bone health Promotes bone formation and increases bone mineral density
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Therefore, in patients with renal insufficiency (assessed by measurement of serum creatinine), serum holoTC concentrations may appear normal, and are no longer a useful biomarker to predict B12 status (Herrmann et al., 2005)
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[23] The hormone has no role in pregnancy maintenance once implantation has occurred, and exogenous administration poses a risk of endocrine disruption or fetal effects
