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Cobalt compounds have been shown to modulate hypoxia-inducible factor-1 (HIF-1), a key regulator of oxygen homeostasis that also controls the expression of various ion channels

Mechanisms of action It has become common to discover a binding of a small molecule to another molecule such as a protein, and assume that this interaction, leading to activation or inhibition of the target, constitutes the mechanism of action of the small molecule at a physiological level

Identification of aflatoxin M1-N7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1

doi: 10.1073/pnas.0502402102

Csiszar A, Ungvari Z, Edwards JG, Kaminski P, Wolin MS, Koller A, Kaley G: Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function

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