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Jacobson and Raff, 1995

During epididymis transport, spermatozoa are vulnerable to intracellular and extracellular ROS attacks and rely on antioxidant scavengers synthesized by the epididymis for protection

The context-dependent regulation of NRF2 creates therapeutic dilemmas: While NRF2 activation shows promise for treating neurodegenerative diseases by enhancing antioxidant defenses, its inhibition may be required in cancers where NRF2 hyperactivation promotes tumor survival and drug resistance

ACSL1-induced ferroptosis and platinum resistance in ovarian cancer by increasing FSP1 N-myristylation and stability

P.SpibyR

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