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In addition to binding bile acids, FXR have been shown to bind polyunsaturated fatty acids (PUFA) such as the omega-3 PUFA docosahexaenoic acid (DHA) and -linolenic acid (ALA)

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Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduces fasting triglycerides and enhances apolipoprotein A-V levels in non-diabetic subjects with hypertriglyceridemia

This chain reaction can affect hundreds of lipid molecules from a single initiation event, amplifying the oxidative damage ( Lipid hydroperoxides, the primary products of lipid peroxidation, are relatively unstable and undergo further reactions