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This prevention of bone loss by Lactobacillus reuteri was attributed to a decrease in osteoclastogenesis and an increase in bone marrow CD4+ T-lymphocytes
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These findings led to the ongoing PROOF-HD phase 3 trial (NCT04556656), which aims to further evaluate its impact using functional endpoints
[DOI] [PubMed] [Google Scholar] 76.Cotto JJ, Morimoto RI
8, CR6906
T Cell Receptor Stimulation, Reactive Oxygen Species, and Cell Signaling
