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doi: 10.1210/jc.2008-0519 40 MeltzerLJMontgomery-DownsHEInsanaSPWalshCM
Topical has clinical trial support
At the 9mg dose, 8.8% of participants experienced dysesthesia
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It was tested in the high and low-dose subgroups (mean of 64 mg of bromelain + 2.7 g of NAC and 183 mg of bromelain plus 7.2 g of NAC respectively)
Some patients develop a sore, red tongue (glossitis) or mouth ulcers
