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Kremer et al., 2024) with an indispensable role of STAT3 activation due to methylation at a CpG site in the GFAP promoter (Takizawa et al., 2001), and in TET1/2/3-mediated DNA demethylation for establishing neural stem cell identity and enabling glial (e.g., astrocyte and oligodendrocyte) differentiation (MacArthur et al., 2024)

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Supplementary information Supplementary Figures 1-18 and Supplementary Tables 1-5

Other studies have also confirmed the importance of the p38 MAPK signaling pathway and its regulators, including pmk-1 , sek-1 (encodes MAPKK), nsy-1 (encodes MAPKKK), and tir-1 (toll-interleukin repeat protein