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In lactate-rich microenvironments, rapid NAD + /NADH turnover imposes strong dependency on NAMPT activity, establishing a lactateNAMPT axis that reinforces the immunoregulatory program of tumor-associated myeloid cells 23

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Next, heme is broken down by heme oxygenase, producing Fe2+, which is then metabolized in the same pathway as non-heme iron (33)