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Garshick explains that "most at-home treatments are temporary in that they improve the overall appearance of the skin and diminish the appearance temporarily, but dont necessarily address the underlying cause." Because cellulite results from changes deeper in the skin, topical treatments are limited in what they can do

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In heart failure, compromised mitochondrial efficiency significantly impairs cardiac function, directly contributing to symptoms of fatigue and limited exercise capacity [106,107,108,109,110,111]