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doi: 10.1002/(SICI)1099-1573(200003)14:2 3.0.CO;2-#

should be avoided

Moderate to Severe Deficiency: For moderate to severe deficiencies, the dosage may increase to 1,000 mcg several times a week initially, followed by a maintenance dose

(2013) investigated ARA-290 in a clinical study examining safety, pharmacokinetics, and metabolic parameters in subjects with type 2 diabetes

Kuzubova NA, Lebedeva ES, Titova ON, Fedin AN, Dvorakovskaya IV

If you need a 250 mcg dose, divide 0.25 mg by 2.5 mg/mL = 0.1 mL
