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Hi all, been SI for about 12 months now and, apart from the occasional bit of slight pain, I've never had any issues

Factors that can increase the risk of B12 deficiency include being over the age of 75, digestive absorption issues, autoimmune conditions, and certain diets like vegetarianism and veganism

Ateyya H, Nader MA, Attia GM, El-Sherbeeny NA (2017) Influence of alpha-lipoic acid on nicotine-induced lung and liver damage in experimental rats

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Additionally, Nampt knockout mice models demonstrated that NAD + depletion in muscle leads to progressive loss of muscle function, while NR treatment restored mitochondrial function and induced muscle remodeling and restoration 255

Many users prefer applying peptide serums first, allowing complete absorption before following with retinol