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One important aspect of migraine is energy metabolism and oxidative stress

During intense physical activity or stress, glutamine levels can drop significantlysometimes by up to 50% after prolonged exercisemaking supplementation valuable for certain individuals

Fatty Acid Oxidation disorders

doi: 10.1139/apnm-2016-0094

Inadequate synthesis of carnitine produces carnitine depletion in dialysis patients, resulting in carnitine depletion and a simultaneous relative rise in esterified carnitine in certain individuals (Matera et al., 2003)
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Arch Dis.Child Fetal Neonatal Ed 1998;78(3):F185-F188
