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MS/MS spectra were matched with peptide sequences using the Comet algorithm along with a composite sequence database including the Human Reference Proteome (2020-01 - SwissProt entries only) UniProt database, as well as sequences of common contaminants

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HGHs anabolic effects are mediated primarily through IGF-1, which then acts on peripheral tissues such as muscle and bone. Laron, Z., Pediatric Endocrinology Reviews IGF-1 LR3: Direct Muscle Growth Stimulator IGF-1 LR3 binds directly to IGF-1 receptors on muscle fibers, triggering: Muscle cell differentiation and proliferation Activation of satellite cells , essential for muscle repair and new muscle fiber growth Enhanced nutrient uptake (glucose, amino acids, creatine) Because of this direct action , IGF-1 LR3 can stimulate local muscle hypertrophy without relying on systemic conversion pathways

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Metabolic syndrome and mammographic density in premenopausal Chilean women