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Persistent activation of cell p53 can lead to the expression of p21, an inhibitor of the cell cycle known as a cyclin-dependent kinase

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However, Chatfield and Hunter (1973) showed that conversion of 2-acetamido-4-chloromethylthiazole to 2-acetamido-4-methylthiomethylthiazole in rats involves the mercapturate pathway and thiomethylation