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Decreased histone deacetylase activity in chronic obstructive pulmonary disease

10.1097/mib.0000000000000684

Studies indicate that A1AT therapy can lead to a reduction in systemic inflammation, as measured by lower CRP levels, thus potentially decreasing the overall inflammatory burden on the lungs ( Moreover, the reduction in inflammatory markers can also be indicative of the therapys effectiveness in mitigating the proteolytic damage caused by neutrophil elastase, which is typically unopposed in AATD patients due to low A1AT levels

Collectively, these findings indicate that curcumin, particularly at higher doses, exerts antidepressant effects through coordinated regulation of multiple interconnected metabolic pathways." - Biophysics Reports | 2026 "Chronic use of curcumin was associated with an inhibition of apoptotic markers and an increase in Bcl-2, indicating a rescue against neurodegeneration and memory impairment

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