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Vilarrasa N, San Jose P, Rubio M, Lecube A

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Recent studies have demonstrated that CSC-derived organoids maintain key features of their parental tumors, including genetic and transcriptomic profiles, drug resistance properties, and metastatic potential

Chl content and ALA-synthesizing capacity consistently remained wild-type-like ( Supplementary Figures 3B, C ) with the striking exception of GSAAT(C190S), which exhibited a significantly lower rate of ALA synthesis

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