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High-dose oral therapy (10002000 micrograms daily) can effectively treat deficiency even in those with impaired intrinsic factor-mediated absorption, relying on passive diffusion

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Studies show that immune checkpoint blockade therapy activates CD8+ T cells to secrete IFN-, promoting ACSL4 growth, regulating cellular acyl-chain phospholipid-fatty acid binding to arachidonic acid (AA), and inducing tumor cell ferroptosis (110)

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White et al., 1998)

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However, in prediabetes and diabetes, this signal is blunted by insulin resistance in the liver

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[PubMed: 11679432] 344

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Kim DS, Choi YP, Kang S, Gao MQ, Kim B, Park HR, Choi YD, Lim JB, Na HJ, Kim HK (2010a) Panel of candidate biomarkers for renal cell carcinoma

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