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[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Rugin D., Hanganu D., Diaconeasa Z., Tbran F., Coman C., Leopold L., Bunea A., Pintea A

Figure 1 Important developments in the field over this time include the first clinical descriptions of the inborn error of metabolism disorder homocystinuria and the subsequent discovery of severe genetic defects in enzymes involved in homocysteine metabolism as causative factors (4)

1 It is hypothesized that occlusion, dilation, and rupture of the hair follicle, along with the resulting inflammation, lead to the symptomatology of HS

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Injection Site Rotation Rotate injection sites to prevent lipodystrophy (fat tissue changes at the injection site)

It occurs due to aging, environmental pollution, exposure to tobacco smoke, alcohol, UV radiation, and dozens of other small factors that add up over time