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5.1 Bone destruction Bone destruction in RA joints presents as localized bone loss, initially involving cortical bone, disrupting the natural barrier between the external bony tissue and trabecular space of the marrow cavity
TGF- has been shown to downregulate activity of Glutamine Cysteine ligase, a rate-limiting step enzyme involved in the synthesis of GSH [75]
The majority of Lyme disease symptoms are therefore attributed to the hosts immune response against the pathogen
