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Inflammation and lung cancer: roles of reactive oxygen/nitrogen species

Adult stem cells in the small intestine are intrinsically programmed with their location-specific function

Areas of uncertainty in toxicity values generally include extrapolation from controlled high-dose animal studies to the human general population (including potentially sensitive subgroups) and generally lower exposure levels, determining if rodent endpoints are relevant to humans (e.g., tumors in the Zymbals gland of rodents), route-to-route extrapolation if toxicity values are lacking for certain exposure pathways, extrapolation from shorter-duration exposure studies to chronic or lifetime risk, and data gaps in the underlying toxicity database

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Khmelnitsky, Y

They further determined that DISC1 regulates activation of the Rho-GTPase RAC1 in the PSD, RAC1 being a protein whose activity modulates spine shape through regulation of actin dynamics (see discussion below)