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Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice

Immunity 2022 , 55 , 12681283

Although other cell death modalities, such as necroptosis and ferroptosis, were not explored, the authors demonstrated how this apoptotic vulnerability could be exploited

The in vitro effective dose can usually be much higher than plasma concentrations that can be attained in humans

Longer uninterrupted dosing is not recommended because receptor sensitivity can diminish without cycling
