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DOI:10.1152/ajprenal.00182.2013 59

Drosophila studies showed 11-16% extension Telomerase activation: In vitro studies confirmed hTERT upregulation in human fetal fibroblasts and pulmonary cells, with treated cells exceeding the Hayflick limit by approximately 10 additional population doublings Telomere elongation: Direct measurements showed statistically significant telomere lengthening in treated cells Cancer incidence: Long-term animal studies showed reduced spontaneous tumor formation, partially addressing the telomerase-cancer concern 2025 validation: An independent study confirmed telomere-lengthening effects across multiple human cell lines, representing the first significant non-Khavinson replication Key limitations: The evidence base is dominated by a single research group

[DOI] [PubMed] [Google Scholar] 68.Yet Kwong Horman J, Patel P, Schultz M, Kraschnewski J

Abstract The pentose phosphate pathway (PPP), which branches from glycolysis at the first committed step of glucose metabolism, is required for the synthesis of ribonucleotides and is a major source of NADPH