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this generally results from genetic variability in the enzymes needed to produce and/or regenerate it 2

10.7554/eLife.12813 Elife 158 StokerT

Curcumin may upregulate glutathione synthesis enzymes through activation of the Nrf2 antioxidant response element pathway (Balogun et al., 2003)

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Genetic damage in Parkin, PTEN Induced Kinase 1 (PINK1) genes and in the DJ-1 protein (which acts as a neuroprotective redox sensor) result in decreased activity of mitochondrial complex I enzyme and decreased adenosine triphosphate (ATP) production (Greco et al., 2023

Homocysteine, vitamin B metabolites, dopamine-substituting compounds, and symptomatology in Parkinsons disease: clinical and therapeutic considerations