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Whether this amount produces meaningful physiological effects compared to placebo has not been rigorously tested

Essentially, high serum B12 can mean that your body is unable to absorb, metabolize, and/or utilize B12 properly, so it remains in your bloodstream

requires nerve biopsy for definitive diagnosis

To evaluate growth on solid media, in all cases -with the exception of the metE mutant, which only grew in the presence of B12 and, therefore, plating with and without B12 was performed from liquid cultures supplemented with B12- the liquid cultures grown without B12 were plated in solid 7H10-ADC plates supplemented with or without AdoCbl (10 g/mL) and/or L-Met (25 g/mL)

How Often Do you Need to Inject Vitamin B Complex