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When free radicals increase, MDA level rise as well

Cell 184 , 28962910.e2813 (2021)

Furthermore, since the autonomic nervous system, especially the sympathetic activity through -adrenergic receptors, has been reported to modulate bone remodeling [9698], it is tempting to speculate that diabetic neuropathy and the resultant dysautonomia probably contribute to bone loss in DM patients

Therefore, a reduction in the formation of Hg-glutathione conjugates minimizes its uptake rate into the kidneys after glomerular filtration of Hg contained in the primary urine, thus favoring the excretion of Hg (Fig