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Safety is also dose- and condition-specific: in the LOVIT sepsis trial published in the New England Journal of Medicine (2022), high-dose IV vitamin C was linked to worse outcomes than placebo, which underscores that more is not always better

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This is followed by further phosphorylation of two additional docking tyrosine residues in the carboxy terminal tail (Tyr1349 and Tyr1356) which on activation can act as degenerate motif to recruit several other subsequent signaling molecules