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Values are expressed as means standard deviation (n=30)

Binding of IRP1 or IRP2 to an IRE can repress translation of transcripts such as ferritin or can increase TfR1 transcript levels by stabilizing the mRNA [4,5]

However, under oxidative stress, Bach1 dissociates from the HO-1 promoter, and stress signals induce the dissociation of Nrf2 from Kelch-like ECH-associated protein 1 (Keap1), which then binds to AREs and initiates the downstream expression of oxidative stress-resistant HO-1 to prevent ROS-induced cellular damage and maintain the organisms antioxidant response (Zhang et al., 2019)

We decided to try and treat both animals as they were still eating, and they were otherwise bright and alert

This wide range of concentrations in the non-diseased brain is likely to be a functional corelate, as suggested by the present findings

17,18,19,20,21 This increase in synaptic glutamate occurs because of decreased tone and function of the extrasynaptic metabotropic glutamate autoreceptors, mGluR2/3, which normally inhibits synaptic glutamate release (this decreased inhibition leads to increased synaptic glutamate) 17,20 and decreased function of glial glutamate transporter-1, which causes reduced glutamate elimination from extracellular space resulting in spillover of synaptic glutamate