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Generally acting as a tumor suppressor, ChaC2 decreases GSH levels in tumor cells, instigates mitochondrial apoptosis and autophagy via UPR and hinders tumor cell proliferation and migration in vitro and in vivo (79)

Understanding cuproptosis through FDX1-mediated lipoylation and proteotoxic stress in Channa punctatus

For example: "My TSH is within range, but my B12 is at the very bottom of the 'normal' limit, and I've been tracking persistent tingling in my feet and brain fog for three weeks

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These observations were also made with mechanistically different secondary stressors such as the mitochondrial complex I inhibitor, rotenone, or proteasomal inhibitors such as MG-132 or bortezomib (Suppl

Coultas DB, Zumwalt RE, Black WC, Sobonya RE (1994) The epidemiology of interstitial lung diseases