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An IVIS Lumina XR imaging system was used to measure bioluminescence intensity 10 min after injection of D-luciferin (Wako Pure Chemical Industries, Osaka, Japan)

Thus, excess GPx1 may alter cellular function by limiting essential levels of hydrogen peroxide to create reductive stress, a condition with an altered redox balance that favors an excess of reducing equivalents that alters cellular redox functions

Considering that iron metabolism, lipid metabolism, and redox pathways coordinately control ferroptosis, we have summarized bioactive molecules that affect ferroptosis by targeting core molecular of these three pathways

mPFC: 22 ASD (2F/20M) and 21 TDC (6F/15M)

10.1021/acsnano.8b09573 53 YangZ

A) Mitochondrial generation of superoxide is a characteristic feature of APAP-induced hepatocyte cell death, which reacts with nitric oxide to form the highly reactive oxidant and nitrating species peroxynitrite, causing extensive protein nitration in mitochondria