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Physical tests in mice Running test Prior to running training/testing, mice were acclimated to the stationary treadmill apparatus (TSE-Systems, USA) for 10 min on two consecutive days (Days 1 and 2)

That is a ceiling, not a target

Understanding these pharmacokinetics helps you set realistic expectations

This review will summarize receptor-related mechanisms that could underlie tolerance especially receptor desensitization

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The K m value was similar to that of the control, but the k cat of both mutants was increased compared to the control (Fig