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Semaglutide and other GLP-1 agonists actually improve glucose metabolism but work through appetite suppression rather than direct fat cell targeting

Cuomo R, Dattilo M, Pumpo R, Capuano G, Boselli L, Budillon G (1994) Nicotinamide methylation in patients with cirrhosis

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In this peptide therapy for fat loss, it works by targeting both glucagon and GLP-1 receptors, helping to reduce hunger, increase satiety, and promote the breakdown of stored fat for energy